Study Particulars
- 12 week randomized, double-blind, placebo-controlled trial during the winter months
- 355 South Asian and white European women, 20-64 years old
- Placebo was unfortified juice with biscuit daily for 12 weeks
- Juice with biscuit fortified with 600 IU (15 mcg) Vitamin D2 or Vitamin D3 daily for 12 weeks
- Lack of dose-response data for vitamin D2 and D3 fortification (only one dose studied)
- This study did not analyse the physiological mechanism behind the different activity of vitamin D2 and D3
- In 2012 Tripkovic (Am J Clin Nutr 95: 1357-1364) published a comprehensive meta-analysis of studies up to and including 2012 that clearly demonstrated the lack of power (small sample sizes) and large variation in the dosage and frequency of administration of vitamin D between studies
- 600 IU of vitamin D2 or D3 is sufficient to achieve and maintain healthy 25(OH)D concentrations >50 nmol/L in the wintertime for those 0-65 y.o. (see Figure)
- A large single or intermittent bolus of vitamin D2 or D3 followed by lower daily doses of vitamin D2 or D3 is not required to achieve and maintain healthy 25(OH)D levels
- Those who consume D2 rich foods such as mushrooms, vitamin D2 fortified bread or vitamin D2 containing supplements can raise their vitamin D levels to near similar levels as those consuming D3 through fish, eggs, or vitamin D3 containing supplements
- 100% vegan-friendly complete multivitamin with a therapeutic dose of vitamin D2 to boost your immunity and bone health
- Contains 1000 IU of vitamin D2 (plant source)
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Hot Topic Small Talk – Volume 2, Number 7
